SUPPORT DOCUMENT #291

Sleep:

    It seems that we really don't know much about why we sleep. I have
suggested that it is a part of energy moderation and some of the
research seems to support that. Here is some of the latest information
from
http://www.britannica.com and its relation to my theory of energy
moderation.. (*) are notes by me. Caps are mine too.

"During sleep, voluntary muscle activities nearly disappear and there is
a decrease in metabolic rate, respiration, heart rate, and  blood
pressure. The activity of the DIGESTIVE SYSTEM INCREASES during the
resting period, but that of the urinary system decreases..."
I have suggested that part of the reason for sleep is  digestion. The
body shuts down to digest the days intake of food.

"Sleep arises most unequivocally in animals that maintain a constant
body temperature and that can be active at a wide range of environmental
temperatures. In such forms, increased metabolic requirements may find
partial compensation in periodic decreases in body temperature and

metabolic rate i.e. during NREM sleep...."

(NREM sleep is 'not rapid eye movement' sleep. It occurs throughout the
night but  that NREM sleep  in the early portion of the sleep period in
humans - for about 3 hours -  seems to be the sleep that best supports
recuperation)

"...Thus the parallel evolution of TEMPERATURE REGULATION  and NREM
sleep has suggested to some authorities that NREM sleep may best be
viewed as a regulatory mechanism conserving energy expenditure in
species whose metabolic requirements are other wise high"
(note human temperature before sleep is generally the highest of the
day. And upon waking is the lowest of the day)

This suggests sleep as energy moderation. I would contend that the above
also accounts  for hibernation in animals.

Just as the hypothalamus seems to have a major impact on most  aspects
of  energy moderation  in humans, it seems to also have a strong impact
on sleep. That suggests that the 2 may be related in some way.

"Sleep can be induced directly by electrical stimulation of certain
areas in the hypothalamus, have been confirmed and extended to other
areas in the brain."

And finally a short experiment that suggests that sleep and digestion
are directly related.
If you have trouble getting up in the morning, and  often feel
sluggish,  try this. Take a half glass of orange juice before bed.
You should wake up earlier than usual and be more alert, rested, and
wide-eyed. The reason, in my opinion is that the acidic OJ  adds more
acid to the stomach thus allowing it to process food faster. Try it and
let me know your results. I think you'll be quite surprised.

SUPPORT DOCUMENT #292

Some loose ends:
Here are some assorted added info on some aspects of my theory.

1. I have suggested that in the RNA world there may have been 2 stranded
RNA that preceded two stranded DNA that we have now. There seems to be
some viruses that still have double  stranded RNA in their genome:
Cystoviridae and Reoviridae.

2.  Osmosis is another example of the 4 options.
If concentration of water is higher outside the cell, water diffuses
into the cell.
This relates to option 1 take in, and option 3 (take in and ) hold in.

If concentration of water is higher inside the cell, water diffuses out
of the cell
this relates to option 2 block out, and option 4 (take in and) excrete
out

3. On Stanley Miller's results: "Miller noted that if the origin of life
requires amino acids more complex than glycine, at least a little
methane must be present in the atmosphere." IF it is found that there
was no methane, then that re-inforces my idea of a GC world that pre
dated the RNA world. Glycine, though it can be coded  4 ways GGC, GGG,
GGA, GGU, would probably have been coded by only G and C's (note almost
all of the amino acids Miller got could be coded by G and C's alone.)

4. Note that in prokaryote cells (and remember 3/5 of earth's history is
prokaryotes alone - 3.5 to 1.4 billion years ago) not only is the
chromosome attached to the plasma membrane, but the plasmids as well.
This to me suggests that the first cell may have been some sort of
protein ball of string that fat later condensed around, though that is
pure conjecture at this point.

5.  Sexual behavior all year long in humans may have had this added
benefit, that it served as a sort of social glue that held interest
between males and females beyond mating periods.

6. Here is another textbook definition of life. I have noted before how
as they are updated, they represent my energy moderation theory more and
more. This is from  BIOLOGICAL SCIENCE, A MOLECULAR APPROACH, BSCS BLUE
VERSION 7TH EDITION. 1996
"The Exobiology Program within NASA, which studies and searches for
extraterrestrial organisms, has adopted the following working
definition:
Life is a self sustained chemical system that is capable of undergoing
Darwinian, or biological evolution."
compare it with my defintion
Life is energy moderation with modification through descent.

7. Photosynthesis has been called the largest chemical process on earth.
If it is such a key to all life, then it should clearly show energy
moderation and it does.
"As temperature increases, the rate of photosynthesis also increases up
to a point where the rate levels off and then declines....showing
optimum temperatures between 20C and 30 C." Biological Science, BSCS
The chart showing optimum temperatures for photosynthesis is almost a
perfect bell curve. The optimum temps seem to fit those of tropical rain
forests. Here are 2 points
1. IF a species of plant (or any other organism that photosynthesizes)
is outside of the optimum temps for photosynthesis (and all other
conditions are similar) it would benefit it, if it  could regulate its
temperature in some way to a more conducive temperature. Any  attempt to
do so would be a type of energy moderation
2. Any species of plant (or photosynthesizer) within that optimum
temperature range, would more easily get enough energy to fit all its
needs, thus allowing it to use it's resources to better evolve in other
ways.

8. Vacuoles in plant cells are vesicles that may occupy more than 50% of
volume in plant cells, they contain water and digestive enzymes, store
nutrients and waste products. This suggests a high development of
options 1 and 3 of the 4 options in plants, which is not in animals. By
itself this is meaningless, yet it suggests that the division of plants
and animals may be another dichotomy based on energy moderation. IF that
is more than just conjecture, then there should be definite differences
in the energy used by  one-celled plants and one-celled animals. The
plants should use less energy, and store more (1 and 3), while the
animal cells, should have higher metabolisms and store less (2 and 4).


SUPPORT DOCUMENT #293

RNA as 2 stranded:
> http://www.virology.net/Big_Virology/BVFamilyGenome.html

> You might find this particularly exciting, Tom, that other RNA viruses don't
> even bother with that reverse transcription step.  No DNA required! - Drox

This is a great site with some amazing photos. I also saw that a couple of the
viruses mentioned had double stranded RNA - which is exciting to me.
It may also be interesting to note this concerning RNA:

SUPPORT DOCUMENT #294

Some more loose ends:

Even the expression of genes  is effected by temperature. Ex. Siamese
cats have a genotype that codes for dark fur but the enzyme produced by
the gene functions best at low temperatures. That part of the animal's
body that has low temperatures, ears, paws, and tail, have dark fur, the
rest of the cat's body is brown or white. If enzyme production works
best at certain temperatures then natural selection would support those
species that can best maintain that temperature. And such coloring could
be vital - for example the Pepper Moth.

Another example is  sperm production in humans. The testis are outside
the body so that the scrotum will have a lower temperature than the body
which helps sperm production. In this example the survival of the
fittest, is that male who can best regulate his body temperature for
maximum sperm production and the production of the healthiest sperm.

In a much broader example;  if ocean temperatures fall a few degrees,
many species that are otherwise well adapted will die. This suggests
that the chemistry for a species is set at a certain optimum range of
temperature. Outside that range species will either die or have to adapt
by regulating that temperature in some way. Also those species that are
in an area where the temperature remains constant, can now use their
energy for other purposes - other than defenses against temperature
variations.

Excess salt can kill organisms. And temperature can exacerbate the
situation. Ex. "When cells freeze, water is removed as pure ice and the
salt solution in which they exist becomes concentrated. Freezing and
drying must have been common hazards from the beginning of life..."
This suggests that those species that would have survived would be those
that either lived in temperate seas, or developed means to protect
themselves from the excess salt by regulating temperature or regulating
salt. The author goes on to talk of salt tolerant bacteria, the
halophiles, yet he adds that it limits their ability to compete with
bacteria when the salinity is normal. In the case of shoreline algae
that synthesize anti salt betaines, "as much as 15% of the dry weight of
shoreline algae is betaine, a considerable diversion of the energy that
would otherwise be available to the organisms." Quotes from James
Lovelock

On my idea of how life began in a GC world. Those GC nucleotide strands
that could best inhibit the melting/denaturing process, would, through
natural selection, be the most likely to survive (not be melted)

James Lovelock suggested the concept of GAIA. To help prove his idea of
earth as a living organism he sets up a simulation he calls DAISYWORLD.
It should be noted that Daisyworld is an energy moderating system (and
one that does not reproduce). And black and white (and later all shades
of daisies) help regulate the temperature of the planet.
His simulation also supported some of my ideas on the 3 modes of natural
selection: - 'the more diverse the system the more fragile it is' (I
suggested this is mode 3 diruptive/abundance) and 'least stress =
greater diversity' (again it matches my mode 3 disruptive/abundance
mode)

The above examples should help show that temperature regulation (energy
regulation) is not just a factor in life, but the
bases of all life development. With this general rule - where
temperature is moderate  and beneficial the organism can evolve his
energy moderating system to other needs. When temperature is disruptive,
the organism must concentrate his energy moderating system on fixing the
problem.

SUPPORT DOCUMENT #295

Here are a few loose ends to assorted threads of my theory of energy
moderation, Hendricks Health Theory:
All quotes from Biological Science BSCS Blue Version 7th ed.

There seem to be 2 basic divisions to the human nervous system. I
believe they are yet another dichotomy that has evolved out of energy
moderation in this way:
"the sympathetic system serves as a stimulator, and is often called the
fight-or-flight system because of its role in preparing an organism to
respond to emergency situations." This  relates to options 2 and 4,
block out and excrete out.

"The parasympathetic system has more of a nurturing role in maintaining
homeostasis. The parasympathetic system also is responsible for moving
food through the digestive tract." This relates to options 1 and 3, take
in and hold in.
****
This textbook quote on homeostasis is also excellent in understanding my
energy moderation theory:
"Organisms exist in constantly changing environments. In order to stay
alive and function properly, all parts of an organism, as well as the
organism itself, must maintain a biological balance within the immediate
environment. This task is accomplished by a variety of mechanisms that
work together to regulate the internal environment of all living
things."
****
When we talk of stress diseases, a better term might be re-stress
diseases. Usually the worst stress comes from unresolved conflicts in
childhood that are triggered by the present moment of stress.
****
Life seems to be that ability to keep an organism within a certain
temperature range that allows the organism to function at its best, or
we could say to better sustain the chemistry of that organism.
If it gets too hot it'll destroy the enzymes that are needed to exist -
and at some point the DNA will denature from the heat. If it gets too
cold the chemistry reactions become sluggish or don't work at all.
Organisms can live outside these boundaries, but it takes most of their
energy to protect themselves. Thus life could be viewed as that ability
to maintain chemical reactions at a temperature where those chemical
reactions work best - energy moderation.
****
I have suggested that there are 2 main ways of being 'fittest': the more
accepted way of out battling competition, but also the way of symbiosis
- working in cooperation with others. A key example of symbiosis is the
child in the mother's womb. That is the basic symbiotic relationship for
humans.
****
(extra) Source for the UCLA study on women and stress response:
James Michael Howard -
> I found the source of the "tend-and-befriend" material you mentioned.  This
> material comes from Psychological Review 2000; 107 (3): 411-429.  Taylor, et
> al.,

SUPPORT DOCUMENT #296

The Health part of the Hendricks Health Theory:

IF I'm correct in suggesting that all life evolved out of energy
moderation ( the main system in humans, being: food in and waste out )
Then it makes sense that resolving the inner conflicts with food in and
waste out, would resolve all the  health problems caused by those inner
conflicts. But what health problems are involved?
(note most inner conflicts with food-in , may be traced back to breast
feeding problems in early childhood
and most inner conflicts with waste out, may be traced back to toilet
training problems in early childhood)

The problems that can be solved or at least  we can alleviate the
severity of, include
most stress, chronic, psychological, and social disorders that don't
have  a specific cause such as: genetic problems, virus, bacteria,
fungi, infections; diet disorders - ex. not enough vitamin C, injury,
sanitary problems, etc..
The test is this. If there are 2 people with all physical conditions
basically the same and one gets a disease or disorder or dysfunction and
the other does not ,  then it is a prime candidate for a possible cure.

First 2 options of energy moderation  - Take in or not take in food

Take in #1 and Block out #2.  Here are the obvious problems it should
help alleviate and/or cure:
colds, sore throats, stuffed nose, mouth sores, asthma, vomiting,
choking, speech problems, food allergies, addiction to: alcohol, drugs,
food; tooth decay, gum problems, lip sores, heartburn, problems with
sense of taste and smell, breast feeding problems, eating disorders -
bulimia, anorexia; and any immune system problems connected with not
being able to block out bad food or excess food, and/or not take in
enough good food in proper amounts.

The other 2 options: Hold in food or excrete out waste
Hold in #3 and excrete out #4 Here are the obvious problems it should
help alleviate and/or cure:
toilet training problems, constipation, diarrhea, gas, anal problems ,
menstruation problems, sexual dysfunction problems, and any immune
system problems of not being able to excrete out what's bad and/or hold
in what's nurturing.

Yet there are other LESS OBVIOUS problems that resolving the inner
conflicts of the 4 options may cure:

Option 1, Any social problems of dependency on others
All disorders labeled as "move towards others" by K. Horney in Inner
Conflicts.

Option 2. Any social problems of violence/anger - the emotions of fight
of the fight-or-flight syndrome
All disorders labeled as 'move against others' by K. Horney

Option 3. Any personal problems of greed, not enough self nurturing, ego
problems,
Any health problems of not being nurtured enough (No K H. disorder)

Option 4.  Any personal problems of fear - the flight in the fight
-or-flight syndrome
Any health problems of not being able to attack the non-self within and
excrete it out (non-self being any cells
that are dangerous to self and are not symbiotic, or harmless), any
problems of separation from others, split personalities (?),
Any disorders labeled as 'move away from others' by K. Horney.

Besides the health benefits to the individual, the key 'health' benefit
will be to resolve repressed anger in
males (option 2) and end or alleviate not only violence against women,
children, and other men, but war.
And, next in importance, resolving the greed problem of option 3 (not
enough nurturing in childhood)  that will support cooperation.

SUPPORT DOCUMENT #296

Single to multi-cell

The best idea I've read on how single cell life may have evolved to
multi -cell life (at least part of those evolutionary steps)
is from "Biology of the Invertebrates" , by Cleveland P. Hickman:

    Also I quote it for another reason. It is difficult to see the 4
options of energy moderation in complex birds and mammals etc. But at
this early stage of multi cell life, it is much more clear. My notes in
(...)
The 4 options again are: 1. take in energy, 2. block out energy, 3. take
in and hold in to nurture, 4. take in and excrete out as waste.

    "Among invertebrate metazoans there is one type of body plan around
which many others are built. This is the saclike, radially symmetric
form in which the cavity is surrounded by a double wall with an outer
layer of cells for protection from the outside (this would be option 2)
and an inner layer for digestion of food (this would be option 3). a
single opening to the outside serves as both mouth (this would be option
1) and anus (this would be option 4) With the addition of tentacles for
food gathering and protection, such a plan is found among the
coelenterates, which are considered to be close to the ancestral base of
metazoans. Digestion in such forms may be partly or wholly intracellular
at first, but a better start is made toward the extracellular digestion
of larger forms than is possible among unicellular organisms..."
(Then it goes on to talk about how cells could specialize from muscular
and nervous elements, sensory elements, secretory cells, shells, etc.)
    "Such a body plan has great possibilities for modification and
specialization. The digestive tube may be much folded, branched,
elongated, or shortened. The body form may be elongated and narrow or
short and broad. This body plan is ideal for division of labor among
communities of cells and is capable, with certain modifications of
attaining a variety of sizes...."
    "The various body plans of the invertebrate Metazoa that have been
built around or derived from a saclike or similar body plan include the
flatworm type with bilateral symmetry and differentiated cephalocaudal
axis, the roundworm type with tube-within-a-tube organization, the
annelid type with segmented body the arthropod type with specialized
somites and jointed appendages, and the molluscan type with mantle and
specialized foot."

    This suggests to me that just about all multi cell life evolved out
of this saclike form. And that the saclike form
is a clear illustration of the 4 options of energy moderation

SUPPORT DOCUMENT #297

Circadian rhythms and other loose ends:

I have suggested that life began as chemicals reacting to the day/night
temperature change (and possibly the dry/wet cycle connected with tides,
as well). If so we should be able to see cycles that correspond to the
world around us in living things. And there are many circadian rhythms
that do just that: "Timing devices are know to be involved in migratory
activities, orientation problems, diurnal and nocturnal activities,
breeding cycles seasonal cycles", etc. etc.

Conjugation in ciliates is another example of  sexual reproduction in
times of severe stress,(asexual reproduction used in times of little
stress)  "Various factors may induce conjugation, such as starvation,
sudden darkness in light conditions, low temperatures, the presence of
certain salts, etc. The process of conjugation may be beneficial in
producing nuclear reorganization and heritable variation and may be
useful in rejuvenation of species." Though the author points out that
conjugation is restricted to certain types of ciliates.

Ciliates also are a good example for how sex determination may be
connected to energy moderation. In one aspect of their reproduction, in
which 4 haploid micronuclei are produced and 3 of those disintegrate,
"The remaining haploid micronucleus now undergoes a mitotic division to
form one haploid stationary pronucleus (female) and one haploid
wandering pronucleus (male)"  Note that the distinctive difference
between the 2 is that one is wandering. It suggests to me an excess of
energy in that one - more so than the other.

In my Health Theory I've suggested that sleep is a part of digestion. If
sleep is upset then food can't be adequately digested and used or
excreted out as waste. Resolving sleep disorders by resolving problems
of the 4 options of energy moderation - is one of the main keys to
health. A key part of sleep problems is that in childhood the child has
no innate or inborn ability to know that dreams and waking reality are
different. This is something that is learned. But what I have found is
that the subconscious retains dream conflicts. And that they must be
brought to the surface and resolved as part of any therapy. I have also
found that these subconscious nightmare fears are much stronger  and
damaging than one can imagine. They must be treated.  If not sleep
disorders will continue leading to all kinds of chronic health problems.

I have suggested that option 1 evolved this way. Take in energy/food
evolved to move toward energy/food and take it in.
This can clearly be seen in ciliates that have food catchers. As they
move through the water either food is swept into the mouth by special
cilia (take in food) or is seized directly (move toward and take in
food).
And it is now easy to see the evolutionary pattern of human infants:
take in mother's milk evolved to move toward breast/food and take in
mother's milk, evolved to move toward mother and take in psychological
nurturing, evolved to move toward nurturing of any kind and move towards
others , etc.

Also it may even be possible to show at least one aspect of mobility as
evolving from food in. Cilia help brush food into the mouth. This
suggests to me (with the other posts in my theory on this subject) that
the evolution line may be something like this:
cilia around the mouth evolves to flagella around the mouth (to catch
food particles) evolves to tentacles around the mouth evolves to legs,
arms, wings, etc.  Though a good case can also be made for flagella at
the back of organisms evolving to legs as well.

An idea that is very intriguing is that life began in sand.  "The minute
fauna found here is probably made up of representatives of every animal
phylum, including many protozoan forms. Within this habitat of sand
grains, air, water, and detritus, the interstitial fauna live in the
passages and spaces between the grains of sand or on the surface of the
sand grains"  It seems that larger sand grains are best - and these
would be most likely in early earth IF it can be determined that they
were present. They would also allow for the cycle of wet and dry that
seems vital for first life to build complexity.

All quotes from The Biology of the Invertebrates, Cleveland P. Hickman

SUPPORT DOCUMENT #299

Here are some more loose ends to my theory.

If life is energy moderation with modification through descent then in
practical terms that is a metabolic system and a replication system
(which I have suggested evolved out of the metabolic system).
If so then parasites would not need the metabolic system - that is
provided by their host. They would only need a replication system. Thus
you would expect them to be very small. "The members of (the Mesozoa)
phylum are considered the simplest multicellular animals ...One common
interpretation considers their simplicity as a secondary adaptation to a
parasitic life ... They are small forms, the largest not exceeding 9 mm.
in length; most are much smaller than this, and some species are under 1
mm. in length. They number about 50 species." Biology of the
Invertebrates.
I tend to think this can be considered a general rule in that most
parasites (bacteria, viruses?) should be very small. See other examples
in my theory.

Speciation seems to me to be like a tree sending seeds out  in hopes
that some will survive and prosper. In the case of species, it seems
like the Genus is the tree that sends out species like seeds. Each has
evolved to fit a certain niche but only some survive. Example in
hominids all but one species either became extinct or evolved into
another. And perhaps we can take the analogy up a step in the ladder and
say the tree is the Family and the seed is the Genus and so forth.
So though almost all species evolve to extinction (evolution leads
species up a creek?) the line is such that its quite likely that one
will survive.

The density problem. "If you take a single bacterium that can reproduce
by fission every 20 minutes under ideal laboratory conditions. At the
end of this time there  would be 2 bacteria, then four after 40 minutes,
and so on. If this continued for only a day and a half - a mere 36 hours
- there would be bacteria enough to form a layer a foot deep over the
entire Earth." But that doesn't happen. In general: "Through mechanisms
that are not yet understood, high densities cause physiological changes
that delay sexual maturation cause reproductive organs to shrink, and
generally inhibit reproduction."  There are some clear reasons - a lack
of food (option  1 problem) too much waste (option 4 problem)
etc. but that is not the complete answer. And my theory does not answer
it. And that question is one that needs to be addressed. It remains a
mystery for now. Quotes from Biology , Campbell

Metabolism and reproduction are not the only evolved 4 options of energy
moderation  in bacteria. Another is directed movement or taxis. "Motile
prokaryotes move toward some substances and away from others. Bacteria
have specific receptor molecules on their membranes that detect the
presence of certain chemicals...The bacterium uses some form of memory
to compare present and past concentrations over short time spans as it
moves along a chemical gradient."  Biology, Campbell.  The moving
towards taxis would have evolved out of option 1 take in/ move toward,
the moving away from taxis would have evolved out of  option 2 block
out, and option 4, excrete out.

The saclike bodies of coelenterates were extremely successful in the
many ways they evolved. On the other hand I think the Volvox type of
colony was a multi cell dead end in that it could not evolve to enough
variations to lead to as much complexity as the coelenterates saclike
body. It might be interesting to do a sci-fi novel on  a highly evolved
volvox type alien, but in the real world - much like giant insects -  I
don't think it could happen. (See my comments on the evolution of nerve
systems out of the alimentary tract)


Temperature presents some problems for mammals and birds:
It must be higher than the environment and it must be more active for
smaller species

"Homeothermic animals generally have body temperatures considerably
higher than the average temperature of their environment. Not only does
a high temperature produce a high metabolic rate and make possible a
high activity level, ... but also it is much easier to maintain a
constant temperature higher than that of the surroundings than one lower
... No mammal or bird could live more than a very short time in an
environment 60 degrees hotter than its body temperature. In fact, few
homeotherms can for long withstand environmental temperatures more than
a few degrees above their body temperature. Their cooling mechanisms are
simply not effective enough. Their metabolism, with its unavoidable heat
production, is by its very nature a furnace, not a refrigeration unit;
it can easily be speeded up to counteract environmental cold, but it
cannot be made into a cooling device .. the most effective thermal
regulatory devices available to animals are based largely on heat
production and conservation, not on heat loss and cooling. Homeothermy,
then involves mechanisms that can produce relative metabolic stability
at a body temperature above that of the environment but not at one much
below that of the environment."

"If the small animal is to maintain its constant high body temperature
despite the rapid heat loss across its body surface, it must oxidize
food materials at a very fast rate. Because excessively small size would
necessitate more food intake, digestion, respiration, etc. per unit time
than would be possible, there is a lower limit on the size of
homeotherms. The smallest living mammals are shrews weighing only about
4 grams. They must eat nearly their own body weight of food every day,
and can starve to death in a few hours if deprived of food."
"Hummingbirds (which are very near the lower size limit for homeotherms)
are active during the day and become dormant, or hibernate during the
night"  "Small mammals belonging to 3 groups - the insectivores, bats,
and rodents - have evolved a mechanism that enables them partly to evade
this problem (of endless eating) When winter comes, they hibernate ..."
Bats not only hibernate during the winter, but also during the daylight
hours.

Also  it is interesting to note that on cold days "butterflies and moths
often vibrate their wings for several minutes before launching into the
air. The heat produced by cellular respiration in the vibrating muscles
may increase the muscle temperature by as much as 15 C in 5 or 6
minutes" thus getting them ready for flight.

"The vast majority of animals and all plants promptly lose most of this
heat (40 - 60 % of the heat of cellular respiration)
to their environments" That's roughly half. It has no benefit for the
organisms, but I wonder if it doesn't help the colony in certain
situations?  (All quotes from Biological Science by  William T. Keeton)

SUPPORT DOCUMENT #300

Here are some final quotes:

"Few organisms can maintain a  sufficiently active metabolism at
temperatures close to o C and temperatures above 50 C denature the
enzymes of most organisms. Extraordinary adaptations enable some
organisms to live outside this temperature range... Most organisms
cannot maintain body temperatures more than a few degrees above or below
the ambient temperature. Mammals and birds are the major exceptions..."
Biology, Campbell

"The metabolism of an organism is very closely tied to temperature (more
than that says I) Within  the narrow range of temperatures to which the
active organism is tolerant, the metabolic rate increases with
increasing temperature and decreases with decreasing temperature in a
very regular fashion ...  As would be expected, the activity of
poikilothermic animals is radically affected by temperature changes in
their environment. As the temperature rises (within narrow limits), they
become more active; as the temperature falls, they become sluggish and
lethargic. Such animals, then , are restricted as to the habitats they
can effectively occupy, because they are at the mercy of the
temperatures in those habitats."  Biological Science William T.  Keeton

It is clear to me that life began as chemicals that reacted to
temperature changes. Through the chemistry of amino acids nucleotides
began to follow that temperature cycle with a denaturing and annealing
cycle. Thus began an energy moderating system that had one trait - the
ability to inhibit too high heat  - one aspect of which was to excrete
out  - which led to replication. In too low heat the chemicals would
slow down until reinvigorated with higher temperature.
This cycle of heat/energy moderation led to the 4 options of energy
moderation - which evolved to all aspects of all life.

ENERGY MODERATION WITH MODIFICATION THROUGH DESCENT